An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use the insulin ...

A revolutionary approach to immune therapy has emerged: engineered immune cells that protect healthy tissue without ...

Mitochondria are well known as the powerhouses of the cell. These crucial, energy generating organelles even have their own little genomes... | Cell And Molecular Biology ...

glucagon secretion is stimulated to promote endogenous glucose production in the liver…while high plasma glucose concentrations trigger insulin secretion from pancreatic beta cells, low- plasma ...

Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.

Researchers have found that end-stage renal disease (ESRD) is much more prevalent in patients with slowly progressive type 1 ...

Senescent cells, or ‘zombie’ cells, are damaged cancer cells that remain active, making it harder to treat tumors.

Researchers at IISc Bengaluru discover potential drug-free treatment for diabetes by enhancing beta-cell function with small molecules.