Inhibition experiments using TNFα and patient-derived anti-adalimumab monoclonal antibodies were performed. Results The antibody response against adalimumab is highly restricted: Fab fragments of a ...

A well-designed CAR+ T assay should be capable of reporting an accurate set of data for its intended use. The assay’s validation parameters will depend on its intended use and any relevant ...

(B) In 6OGE, two different antibodies bind to distinct epitopes of the same antigen. (C) In 3BQU, an anti-idiotypic antibody binds exclusively to a single chain of the antibody. (A) Antibody fragment ...

BACKGROUND The anti-idiotypic monoclonal antibody 105AD7 mimics the tumour associated antigen 791Tgp72, expressed on 70–80% of colorectal cancers. Phase I studies have shown that the vaccine is ...

Bispecific antibodies represent an innovative paradigm in cancer therapy ... protease-activated bsAbs are engineered using diverse masking strategies, such as (i) mimotopes and idiotypic masks; (ii) ...

The following antibodies were used for phenotyping and proliferation ... Cell Signaling, Danvers, MA), anti-FMC19 idiotype APC (Juno Therapeutics), anti-EGFRt PE (Juno Therapeutics), anti-CD28 APC ...

Testing for antinuclear antibodies (ANA) and C reactive protein (CRP ... or in-house modifications of the ELISA protocol (eg, pH-shift-anti-idiotype ABT,29 mobility-shift assay30). Our data ...

By targeting surface markers on cancer cells, engineered synthetic receptors expressed on immune cells can be directed to ...

A significant percentage of patients with Lyme arthritis and other Lyme disease manifestations were positive for anti-RA33 antibodies.

Their finding is published in Science Immunology in an article titled, “Anti-Immune Complex Antibodies are Elicited During Repeated Immunization with HIV Env Immunogens,” and could lead to ...