PROFILE Trial: Top-Down Outperforms Step-Up Treatment for …
Dec 26, 2024 · TOP-DOWN treatment for newly diagnosed Crohn’s disease significantly outperforms the conventional accelerated step-up approach, according to PROFILE, a multicentre, open-label, biomarker-stratified, randomised controlled trial.. The study, conducted between December 2017–January 2022, enrolled 386 adults with active Crohn’s disease …
May 2, 2024 · Abbreviations: AML: acute myeloid leukemia; CCUS: clonal cytopenia of undetermined significance; del: deletion; EB: excess blasts; FISH: fluorescence in situ ...
EMJ | Elevating the quality of healthcare globally
In this episode, Jonathan Sackier sits down with Tom Bradshaw to explore the rapidly evolving landscape of digital health. They discuss Bradshaw’s expertise in the clinical application of AI and digital technologies, his work with the NHS and private sector firms, and more.
CC B Ó-NC . Licence É Copyright 22 EMJ É August 22 É Neurology 51 Meeting Summary Nipocalimab, a high-affinity, fully human, aglycosylated, effectorless ...
Radiation Therapy Shows Promise for Liver Cancer Survival
Dec 29, 2024 · A phase 3 clinical trial suggests that stereotactic body radiation therapy (SBRT) prior to systemic treatment may improve survival outcomes for patients with locally advanced hepatocellular carcinoma (HCC), although the findings were not statistically significant. The trial compared the effects of ...
Yet, up to 55% of patients can be lost to follow-up after presenting as an emergency with food impaction.7 Regular assessment, every 12–24 months, may
The Advances in Treatment Options for Conditions Causing Hair Loss
Nov 7, 2024 · DRUGS. Oral and topical JAK inhibitors have emerged as promising treatments for autoimmune-related hair loss, particularly alopecia areata. 3 JAK inhibitors function through inhibition of enzymes in the JAK/signal transducer and activator of transcription (STAT) signalling pathway, regulating immune system activity. Currently, three JAK inhibitors have been …
Oct 4, 2024 · 2 Factor XI/XIa Inhibitors: What We Now Know Interview Interview Summary The emerging class of agents targeting factor XI/XIa offers the paradigm-
COVID-19 Spike Protein Persists in Brain Tissues for Years
Dec 10, 2024 · DATA have revealed that SARS-CoV-2 spike protein persists in brain-protective tissues and skull bone marrow for years post-infection, potentially driving long COVID neurological symptoms, though mRNA vaccines reduce this burden by 50%.. A groundbreaking study has revealed that the SARS-CoV-2 spike protein can remain in the skull’s bone marrow and brain …
New Psoriasis Antibody Treatment Shows Exceptional Clinical Results
Dec 24, 2024 · PSORIASIS, a chronic immune-mediated skin condition, poses a significant challenge for patients, with an ongoing unmet need for effective biologic treatments. To address this, a recent randomised clinical trial evaluated the safety, pharmacokinetics, and efficacy of QX004N in both healthy individuals and patients with moderate to severe plaque psoriasis in …